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مهندسی داروسازی +pharmaceutical engineering - کاربرد نرم افزار Aspen در مهندسی داروسازی

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کاربرد نرم افزار Aspen در مهندسی داروسازی

نویسنده :یوسفی +09187135911
تاریخ:جمعه 15 شهریور 1392-02:43 ب.ظ

در پاسخ به سوال دوستان که آیا نرم افزارهایی مثل Aspen و Hysis در داروسازی کاربرد دارند یا نه مطالب زیر ارائه می شود:

نرم افزار Aspen  در زمینه داروسازی دو ماژول اختصاصی دارد که شامل:

1- Aspen batch: که برای طراحی فرایندهای داروسازی کاربرد دارد ولی user friendly نمی باشد و توصیه می شود که از نرم افزار قدرتمند suprepro designer در این زمینه استفاده کنید.

2- Aspen Solubility:  این ماژول در شرکت های داروسازی بسیار کاربرد دارد. از این ماژول شرکت های بزرگی چون Bristol-Myers Squibb Co، برای انتخاب بهترین حلال در طراحی مفهومی یک API جدید استفاده کرده اند و نتیجه را به صورت مقاله تحت عنوان

Model-Based Solvent Selection during Conceptual Process Design of a New Drug Manufacturing Process

 منتشر کرده اند (پایه این روش را آقای چن به صورت NRTL-SAC برای اولین بار در سال 2004 در مقاله ای چاپ کرده اند).

یک مورد دیگر شرکت Eli Lilly را می توان نام برد که از این روش و از این نرم افزار برای انتخاب بهترین حلال برای فرایند کریستالیزاسیون استفاده کرده اند و نتیجه کار را تحت عنوان

Modeling Drug Molecule Solubility to Identify Optimal Solvent Systems for Crystallization

چاپ کرده اند.

به طور کلی کاربرد های این ماژول شامل:

1- Solubility in solvents

2- free energy of mixing

3- اثرات دما روی میزان انحلال پذیری یک دارو (تغییرات انحلال پذیری با تغییر دما)

4- محاسبه logp

5- غربالگیری انحلال پذیری دارو ها در هزاران مخلوط های دوتایی حلال و کمک حلال (دارای آرشیو بسیار قوی انواع حلال)

6- انحلال پذیری دارو در مخلوط های دوتایی

7- انحلال پذیری در مخلوط های سه تایی

8- phase diagram for VLE

9- phase diagram for LLE

10- Ternary phase diagram

11- انتخاب بهترین حلال و ضد حلال و ترکیب درصد آن ها برای فرایند کرستالیزاسیون

 

 




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